autoimmune disease — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5310	TR-14035	MDK-1191	Integrin
	TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).		Integrin
T12079	ML604440		Proteasome
	ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.		Proteasome
T60012	HS-243		IRAK , MAPK , CDK
	HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.		IRAK , MAPK , CDK
T38078	TLR7/8-IN-1	TLR7/8-IN-1	TLR
	TLR7/8-IN-1, a crystalline TLR7/TLR8 inhibitor, is a valuable compound for autoimmune disease research[1].		TLR
T80678	(S)-AK-242	(-)-Resatorvid,(S)-Resatorvid,AK-242 (S enantiomer),(-)-AK-242	Others
	(S)-AK-242 ((S)-Resatorvid) is a cytokine inhibitor used in the treatment of heart disease, autoimmune disease, and inflammatory disease.		Others
T4644	Tapinarof	GSK2894512,Benvitimod,WBI 1001	AhR , Aryl Hydrocarbon Receptor
	Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.		AhR , Aryl Hydrocarbon Receptor
T62858	HGPR91 antagonist 3		GPR
	hGPR91 antagonist 3 is an orally active, potent, and selective hGPR91 antagonist. hGPR91 antagonist 3 is used to study hypertension, autoimmune diseases, and retinal angiogenesis. hGPR91 antagonist 3 has been shown to be...		GPR
T10835	Cletoquine	Desethylhydroxychloroquine	Parasite , Antifection
	Cletoquine is a major active metabolite of Hydroxychloroquine. Cletoquine has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune disease treatme...		Parasite , Antifection
T68043	Ciamexon	Ciamexone,BM 41332,BM41332,BM-41332	Others
	Ciamexon (Ciamexone) is a novel immunomodulator that has shown promising results in experimental models of autoimmune disease with little demonstrated cytotoxicity.Ciamexon can be used to study endocrine ophthalmopathies...		Others
T78525	IRG1-IN-1		Others
	IRG1-IN-1 is an itaconic acid derivative with the ability to inhibit the activity of Immune Response Gene 1 (IRG1) and is suitable for use in the field of cancer, inflammation and autoimmune disease research.		Others
T73695	Canakinumab	ACZ 885,Ilaris	IL Receptor
	Canakinumab (ACZ885) is a recombinant human IL-1β-targeting monoclonal antibody.Canakinumab has been shown to inhibit human and chorioallantoic monkey IL-1β, with IC50 values of 43.6 and 40.8 pM, respectively.Canakinumab...		IL Receptor
T3877	Esculentoside A		NF-κB , COX
	Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. Esculentoside A may be useful for the treatment of autoimmun...		NF-κB , COX
T3701	MCC950	CP-456773	NOD
	CP-456773 (MCC950 (CP-456773) and CRID3) is an effective and specific cytokine release inhibitor and NLRP3 inflammasome inhibitor. CP-456773 inhibits IL-1β secretion and caspase 1 processing. MCC950 blocked canonical and...		NOD
T39327	Amdizalisib	Amdizalisib,HMPL-689
	Amdizalisib is a PI3K inhibitor and used for the research of inflammatory disease, autoimmune disease or cancer.
TP1362	Angiogenin (108-122)	Angiogenin 108-122
	Angiogenin (108-122) is an angiogenin peptide. Angiogenin (108-122) acts as a therapeutic agent for the prophylaxis and/or treatment of cancer, an infectious disease, a fibrotic disease, an inflammatory disease, a neurod...
T79094	Bromodomain inhibitor-12 (edisylate)		Epigenetic Reader Domain
	Bromodomain Inhibitor-12 Edisylate (example 303) serves as a bromodomain inhibitor applicable to autoimmune and inflammatory disease research [1].		Epigenetic Reader Domain
T10835L	Cletoquine oxalate	Desethylhydroxychloroquine oxalate	Others
	Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has...		Others
T79816	S1P1 agonist 6		LPL Receptor
	Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive agent in autoimmune disease research [1].		LPL Receptor
TP1320	Angiogenin (108-122) TFA (112173-49-6 free base)	Angiogenin (108-122) TFA
	Angiogenin (108-122) TFA is an angiogenin peptide.Angiogenin (108-122) acts as a therapeutic agent for the prophylaxis and/or treatment of cancer, an infectious disease, a fibrotic disease, an inflammatory disease, a neu...
T25109	ARN-6039	ARN 6039,ARN6039
	ARN-6039 is an orally available inverse agonist of RORγ for Autoimmune Neuroinflammatory Demyelinating Disease. The activity of ARN-6039 against RORγ was demonstrated in a RORγ-activated IL-17A Prom/LUCPorter assay in HE...